mtx 531 Search Results


mtx 531  (MedChemExpress)
94
MedChemExpress mtx 531
A-B, D-E, G-H. Plots showing the percentage of anastasis normalized to the control in cells treated 5h with 150ng/ml (A, D, G) or 250ng/ml DOX (B, E, H), and washed with different concentrations of the Akt inhibitor ALM301 (A, B), the PI3K inhibitor LY29004 (D, E), or the dual EGFR/PI3K <t>inhibitor</t> <t>MTX-531</t> (G, H). Although 100µM MTX-531 is the most lethal condition, the plotted curve does not fully capture this effect because extensive cell death led to aggregation, which interfered with accurate detection of anastatic cells and artificially increased their measured frequency (G-H, *Artifact). Different treatments are shown in distinct colors. The positive control (qVD-Oph) is shown in black. Data were normalized by subtraction. Data and error bars were smoothed. Error bars represent the mean ± SD from n=2 independent experiments. C. Plot showing the percentage confluence normalized to its initial value in cells that were not exposed to DOX for ALM301 treatment. F, I. Images comparing the effects of 10µM and 100µM LY294002 (F) or MTX-531 (I) and the corresponding DMSO controls in cells that were not exposed to DOX at the end of our experiment.
Mtx 531, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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mtx 531 - by Bioz Stars, 2026-03
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mtx-531  (WuXi AppTec)
90
WuXi AppTec mtx-531
A-B, D-E, G-H. Plots showing the percentage of anastasis normalized to the control in cells treated 5h with 150ng/ml (A, D, G) or 250ng/ml DOX (B, E, H), and washed with different concentrations of the Akt inhibitor ALM301 (A, B), the PI3K inhibitor LY29004 (D, E), or the dual EGFR/PI3K <t>inhibitor</t> <t>MTX-531</t> (G, H). Although 100µM MTX-531 is the most lethal condition, the plotted curve does not fully capture this effect because extensive cell death led to aggregation, which interfered with accurate detection of anastatic cells and artificially increased their measured frequency (G-H, *Artifact). Different treatments are shown in distinct colors. The positive control (qVD-Oph) is shown in black. Data were normalized by subtraction. Data and error bars were smoothed. Error bars represent the mean ± SD from n=2 independent experiments. C. Plot showing the percentage confluence normalized to its initial value in cells that were not exposed to DOX for ALM301 treatment. F, I. Images comparing the effects of 10µM and 100µM LY294002 (F) or MTX-531 (I) and the corresponding DMSO controls in cells that were not exposed to DOX at the end of our experiment.
Mtx 531, supplied by WuXi AppTec, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/mtx-531/product/WuXi AppTec
Average 90 stars, based on 1 article reviews
mtx-531 - by Bioz Stars, 2026-03
90/100 stars
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Image Search Results


A-B, D-E, G-H. Plots showing the percentage of anastasis normalized to the control in cells treated 5h with 150ng/ml (A, D, G) or 250ng/ml DOX (B, E, H), and washed with different concentrations of the Akt inhibitor ALM301 (A, B), the PI3K inhibitor LY29004 (D, E), or the dual EGFR/PI3K inhibitor MTX-531 (G, H). Although 100µM MTX-531 is the most lethal condition, the plotted curve does not fully capture this effect because extensive cell death led to aggregation, which interfered with accurate detection of anastatic cells and artificially increased their measured frequency (G-H, *Artifact). Different treatments are shown in distinct colors. The positive control (qVD-Oph) is shown in black. Data were normalized by subtraction. Data and error bars were smoothed. Error bars represent the mean ± SD from n=2 independent experiments. C. Plot showing the percentage confluence normalized to its initial value in cells that were not exposed to DOX for ALM301 treatment. F, I. Images comparing the effects of 10µM and 100µM LY294002 (F) or MTX-531 (I) and the corresponding DMSO controls in cells that were not exposed to DOX at the end of our experiment.

Journal: bioRxiv

Article Title: A kinome inhibitor screen implicates adhesion and growth factor signaling in cellular recovery after caspase activation

doi: 10.64898/2026.01.06.697929

Figure Lengend Snippet: A-B, D-E, G-H. Plots showing the percentage of anastasis normalized to the control in cells treated 5h with 150ng/ml (A, D, G) or 250ng/ml DOX (B, E, H), and washed with different concentrations of the Akt inhibitor ALM301 (A, B), the PI3K inhibitor LY29004 (D, E), or the dual EGFR/PI3K inhibitor MTX-531 (G, H). Although 100µM MTX-531 is the most lethal condition, the plotted curve does not fully capture this effect because extensive cell death led to aggregation, which interfered with accurate detection of anastatic cells and artificially increased their measured frequency (G-H, *Artifact). Different treatments are shown in distinct colors. The positive control (qVD-Oph) is shown in black. Data were normalized by subtraction. Data and error bars were smoothed. Error bars represent the mean ± SD from n=2 independent experiments. C. Plot showing the percentage confluence normalized to its initial value in cells that were not exposed to DOX for ALM301 treatment. F, I. Images comparing the effects of 10µM and 100µM LY294002 (F) or MTX-531 (I) and the corresponding DMSO controls in cells that were not exposed to DOX at the end of our experiment.

Article Snippet: We used ALM301 (CAS #1313439-71-2) to inhibit Akt (cat#HY-151504, MedChemExpress) , LY294002 (CAS #154447-36-6) to inhibit PI3K (cat#PHZ1144, Thermo Fisher Scientific) ( , ), MTX-531 (CAS #2791417-66-6) to inhibit EGFR/PI3K (cat#43038, Cayman Chemicals) , and rapamycin (CAS #53123-88-9) to inhibit mTOR (cat#HY-10219, MedChemExpress) ( ).

Techniques: Control, Positive Control